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The study findings provide a drug target for the disease, said lead study author Jayakrishnan Nandakumar, assistant professor of molecular, cellular and developmental biology at the University of Michigan. The mutation compromises the function of an enzyme known as telomerase , which fuels stem cell division, he said. Stem cells must divide to repair old tissue. This mutation, which occurs in the telomere protein TPP1, causes stem cells to slow or stop dividing in people with this rare, incurable disease. This can cause tissue breakdown, premature aging, bone marrow failure, cancer and even death. Nandakumar and his U-M colleagues are believed to be the first to use genome editing technology called CRISPR/CAS9 to introduce a dyskeratosis congenita mutation into human cells. This gene editing technology is often described as a pair of molecular scissors, because it cuts DNA in precise locations to allow for additions, deletions and replacements of DNA near the cut. The acronym...

Medical utilization of particular floor antigen GFRA2: Utilizing GFRA2 as a cell floor marker, cardiac precursor cells could be sorted for fundamental analysis of cardiomyocyte , pharmacological take a look at, or regeneration/cell substitute remedy for the center failure. Credit score: Picture courtesy of Osaka College The center is among the first organs to emerge as cardiac progenitors within the embryo. To this point, varied research have elevated our information of how cardiac progenitors develop after which differentiate into functionally totally different cell varieties within the coronary heart. Such information is extraordinarily crucial to grasp the pathological reason for congenital coronary heart ailments in addition to to supply the center muscle cells, known as cardiomyocytes, from embryonic or induced pluripotent stem (ES or iPS) cells in laboratories. ...